Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration

Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exch...

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Bibliographic Details
Published in:Amino acids 2002-01, Vol.23 (1-3), p.161-162
Main Authors: Baker, D A, Shen, H, Kalivas, P W
Format: Article
Language:English
Subjects:
Animals
Biological Transport - drug effects
Biological Transport - physiology
Calcium Channel Blockers - pharmacology
Cocaine - administration & dosage
Cocaine - pharmacology
Cystine - metabolism
Diltiazem - pharmacology
Dopamine Uptake Inhibitors - administration & dosage
Dopamine Uptake Inhibitors - pharmacology
Glutamic Acid - metabolism
Microdialysis
Nucleus Accumbens - drug effects
Nucleus Accumbens - metabolism
omega-Conotoxins - pharmacology
Rats
Tetrodotoxin - pharmacology
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Summary:Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-001-0122-6