Preparation of chitosan–tannic acid coating and its anti-osteoclast and antibacterial activities in titanium implants

Introduction Bacterial infection and aseptic loosening caused by bone resorption at the implant interface are major clinical complications during bone defect implantation surgery, and surface modification of the implant to address the aforementioned problems has long been a research focus. Materials...

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Bibliographic Details
Published in:Journal of bone and mineral metabolism 2022-05, Vol.40 (3), p.402-414
Main Authors: Liao, Bo, Xu, Cheng, Wang, Zhenglun, Li, Wei, Liu, Xinyu, Lu, Dong
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Chitosan - chemistry
Chitosan - pharmacology
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
Escherichia coli
Medicine
Medicine & Public Health
Metabolic Diseases
Original Article
Orthopedics
Osteoclasts
Tannins - chemistry
Tannins - pharmacology
Titanium - chemistry
Titanium - pharmacology
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Summary:Introduction Bacterial infection and aseptic loosening caused by bone resorption at the implant interface are major clinical complications during bone defect implantation surgery, and surface modification of the implant to address the aforementioned problems has long been a research focus. Materials and methods In this paper, a chitosan (CTS)–tannic acid (TA) colloid coating with a negative charge and excellent hydrophilicity was prepared on a Ti6Al4V (TC4) surface using a layer-by-layer assembly method. The physical properties, anti-osteoclast activity, and antimicrobial activity of the coatings were investigated. Results The findings showed that when the pH value was 5 and the ratio of CTS:TA was 0.8, the carrying rate of TA was the best. Furthermore, the CTS–TA coating had no cytotoxicity on the morphology and proliferation of BMSCs cells and effectively inhibited the differentiation of RAW264.7 cells into osteoclasts and the proliferation of Staphylococcus aureus and Escherichia coli. With the increase in the immersion time of TC4 in CTS–TA colloid solution, the inhibitory effects will also enhance. Conclusion Therefore, the preparation of the CTS–TA coating provides a revolutionary technique for implant surface modification to avoid postoperative bacterial infection and aseptic loosening.
ISSN:0914-8779
1435-5604
DOI:10.1007/s00774-022-01309-7