Dual-rhodamine urea derivative, a novel chemidosimeter for Hg(II) and its application in imaging Hg(II) in living cells

The synthesis and spectral properties of a chemidosimeter 1,4-di[2-(6-ethylamino-3-ethylimino-2,7-dimethyl-3H-xanthen-9-yl) benzoic acid (aminomethyl)-3-phenylthiourea] benzene (1) for Hg(II) ions are reported, and it has been demonstrated that 1 can be used as a fluorescent probe for monitoring Hg(...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biological inorganic chemistry 2009-08, Vol.14 (6), p.815-819
Main Authors: Xi, Pin-xian, Huang, Liang, Liu, Heng, Jia, Peng-fei, Chen, Feng-juan, Xu, Min, Zeng, Zheng-zhi
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Cell Survival
Cells - chemistry
Cells - cytology
Environmental Pollutants - analysis
Fluorescent Dyes - chemistry
HeLa Cells
Humans
Hydrogen-Ion Concentration
Life Sciences
Mercury - analysis
Microbiology
Rhodamines - chemistry
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Temperature
Urea - analogs & derivatives
Urea - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis and spectral properties of a chemidosimeter 1,4-di[2-(6-ethylamino-3-ethylimino-2,7-dimethyl-3H-xanthen-9-yl) benzoic acid (aminomethyl)-3-phenylthiourea] benzene (1) for Hg(II) ions are reported, and it has been demonstrated that 1 can be used as a fluorescent probe for monitoring Hg(II) ions in living cells. Graphical abstract A highly sensitive fluorescent probe (1) was developed as a fluorescent and colorimetric chemodosimeter in dimethyl sulfoxide/methanol solution with a broad pH range (pH 5-10) and high selectivity toward Hg²⁺ ions but no significant response toward other competitive cations. Furthermore, by means of confocal laser scanning microscopy experiments, it is demonstrated that 1 can be used as a fluorescent probe for monitoring Hg²⁺ in living cells. [graphic removed]
ISSN:0949-8257
1432-1327
DOI:10.1007/s00775-009-0546-0