Oral administration of coenzyme Q10 reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice

The neuroprotective effect of coenzyme Q 10 (CoQ 10 ) has been reported in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ 10 could protect the striatal dopaminergic (DAergic) nerve terminals against MPTP-induced tox...

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Published in:Neurological sciences 2012-02, Vol.33 (1), p.195-199
Main Authors: Kobayashi, Shota, Muroyama, Akiko, Matsushima, Hiroaki, Yoshimura, Ikuo, Mitsumoto, Yasuhide
Format: Article
Language:English
Subjects:
Animals
Brief Communication
Corpus Striatum - drug effects
Corpus Striatum - pathology
Dopaminergic Neurons - drug effects
Dopaminergic Neurons - pathology
Male
Medicine
Medicine & Public Health
Mice
MPTP Poisoning - drug therapy
MPTP Poisoning - pathology
Neurology
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Neuroradiology
Neurosurgery
Psychiatry
Ubiquinone - pharmacology
Ubiquinone - therapeutic use
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Summary:The neuroprotective effect of coenzyme Q 10 (CoQ 10 ) has been reported in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ 10 could protect the striatal dopaminergic (DAergic) nerve terminals against MPTP-induced toxicity in C57BL/6N mice using immunoisolation technique for DAergic synaptosomes. CoQ 10 significantly attenuated decrease in dopamine transporter as well as in synaptophysin and actin protein levels in DAergic synaptosomes from MPTP-treated mice. The effect of CoQ 10 was also observed in crude synaptosomes fraction, but not in homogenate. Our results indicate that the nerve terminals are a site for the action of CoQ 10 against the MPTP-induced DAergic neurodegeneration.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-011-0627-z