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Oral administration of coenzyme Q10 reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice
The neuroprotective effect of coenzyme Q 10 (CoQ 10 ) has been reported in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ 10 could protect the striatal dopaminergic (DAergic) nerve terminals against MPTP-induced tox...
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| Published in: | Neurological sciences 2012-02, Vol.33 (1), p.195-199 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 199 |
| container_issue | 1 |
| container_start_page | 195 |
| container_title | Neurological sciences |
| container_volume | 33 |
| creator | Kobayashi, Shota Muroyama, Akiko Matsushima, Hiroaki Yoshimura, Ikuo Mitsumoto, Yasuhide |
| description | The neuroprotective effect of coenzyme Q
10
(CoQ
10
) has been reported in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ
10
could protect the striatal dopaminergic (DAergic) nerve terminals against MPTP-induced toxicity in C57BL/6N mice using immunoisolation technique for DAergic synaptosomes. CoQ
10
significantly attenuated decrease in dopamine transporter as well as in synaptophysin and actin protein levels in DAergic synaptosomes from MPTP-treated mice. The effect of CoQ
10
was also observed in crude synaptosomes fraction, but not in homogenate. Our results indicate that the nerve terminals are a site for the action of CoQ
10
against the MPTP-induced DAergic neurodegeneration. |
| doi_str_mv | 10.1007/s10072-011-0627-z |
| format | article |
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10
(CoQ
10
) has been reported in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ
10
could protect the striatal dopaminergic (DAergic) nerve terminals against MPTP-induced toxicity in C57BL/6N mice using immunoisolation technique for DAergic synaptosomes. CoQ
10
significantly attenuated decrease in dopamine transporter as well as in synaptophysin and actin protein levels in DAergic synaptosomes from MPTP-treated mice. The effect of CoQ
10
was also observed in crude synaptosomes fraction, but not in homogenate. Our results indicate that the nerve terminals are a site for the action of CoQ
10
against the MPTP-induced DAergic neurodegeneration.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-011-0627-z</identifier><identifier>PMID: 21598008</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Animals ; Brief Communication ; Corpus Striatum - drug effects ; Corpus Striatum - pathology ; Dopaminergic Neurons - drug effects ; Dopaminergic Neurons - pathology ; Male ; Medicine ; Medicine & Public Health ; Mice ; MPTP Poisoning - drug therapy ; MPTP Poisoning - pathology ; Neurology ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; Neuroradiology ; Neurosurgery ; Psychiatry ; Ubiquinone - pharmacology ; Ubiquinone - therapeutic use</subject><ispartof>Neurological sciences, 2012-02, Vol.33 (1), p.195-199</ispartof><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c254z-938bb5d303e39596024f5366248a886dc351bc2dee9eb5a0df5fb2108e4f1d7f3</citedby><cites>FETCH-LOGICAL-c254z-938bb5d303e39596024f5366248a886dc351bc2dee9eb5a0df5fb2108e4f1d7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21598008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobayashi, Shota</creatorcontrib><creatorcontrib>Muroyama, Akiko</creatorcontrib><creatorcontrib>Matsushima, Hiroaki</creatorcontrib><creatorcontrib>Yoshimura, Ikuo</creatorcontrib><creatorcontrib>Mitsumoto, Yasuhide</creatorcontrib><title>Oral administration of coenzyme Q10 reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>The neuroprotective effect of coenzyme Q
10
(CoQ
10
) has been reported in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ
10
could protect the striatal dopaminergic (DAergic) nerve terminals against MPTP-induced toxicity in C57BL/6N mice using immunoisolation technique for DAergic synaptosomes. CoQ
10
significantly attenuated decrease in dopamine transporter as well as in synaptophysin and actin protein levels in DAergic synaptosomes from MPTP-treated mice. The effect of CoQ
10
was also observed in crude synaptosomes fraction, but not in homogenate. Our results indicate that the nerve terminals are a site for the action of CoQ
10
against the MPTP-induced DAergic neurodegeneration.</description><subject>Animals</subject><subject>Brief Communication</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - pathology</subject><subject>Dopaminergic Neurons - drug effects</subject><subject>Dopaminergic Neurons - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>MPTP Poisoning - drug therapy</subject><subject>MPTP Poisoning - pathology</subject><subject>Neurology</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Psychiatry</subject><subject>Ubiquinone - pharmacology</subject><subject>Ubiquinone - therapeutic use</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9UMlOwzAQtRCIlsIHcEH-AcPYzuIcUcUmFbVI5Rw58aS4apLKTpCar8dRC0cus_gtGj9Cbjncc4D0wY9VMOCcQSJSNpyRKY8zYDJK1flp5iqNJuTK-y0A8IjLSzIRAVEAakr6pdM7qk1tG-s7pzvbNrStaNliMxxqpB8cqEPTl-jp-2q9YrYZF0N3rfcj07R7HdToNrakoX0j7dCFF73z1Da0-0IanK3u-nrca1viNbmoAow3pz4jn89P6_krWyxf3uaPC1aKOBpYJlVRxEaCRJnFWQIiqmKZJCJSWqnElDLmRSkMYoZFrMFUcVUIDgqjipu0kjPCj76lC9c6rPK9s7V2h5xDPoaXHyPMQ4T5GGE-BM3dUbPvixrNn-I3s0AQR4IPULNBl2_b3o3f_cf1B0Sufh8</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Kobayashi, Shota</creator><creator>Muroyama, Akiko</creator><creator>Matsushima, Hiroaki</creator><creator>Yoshimura, Ikuo</creator><creator>Mitsumoto, Yasuhide</creator><general>Springer Milan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201202</creationdate><title>Oral administration of coenzyme Q10 reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice</title><author>Kobayashi, Shota ; Muroyama, Akiko ; Matsushima, Hiroaki ; Yoshimura, Ikuo ; Mitsumoto, Yasuhide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c254z-938bb5d303e39596024f5366248a886dc351bc2dee9eb5a0df5fb2108e4f1d7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Brief Communication</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - pathology</topic><topic>Dopaminergic Neurons - drug effects</topic><topic>Dopaminergic Neurons - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>MPTP Poisoning - drug therapy</topic><topic>MPTP Poisoning - pathology</topic><topic>Neurology</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Psychiatry</topic><topic>Ubiquinone - pharmacology</topic><topic>Ubiquinone - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayashi, Shota</creatorcontrib><creatorcontrib>Muroyama, Akiko</creatorcontrib><creatorcontrib>Matsushima, Hiroaki</creatorcontrib><creatorcontrib>Yoshimura, Ikuo</creatorcontrib><creatorcontrib>Mitsumoto, Yasuhide</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Shota</au><au>Muroyama, Akiko</au><au>Matsushima, Hiroaki</au><au>Yoshimura, Ikuo</au><au>Mitsumoto, Yasuhide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral administration of coenzyme Q10 reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2012-02</date><risdate>2012</risdate><volume>33</volume><issue>1</issue><spage>195</spage><epage>199</epage><pages>195-199</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>The neuroprotective effect of coenzyme Q
10
(CoQ
10
) has been reported in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ
10
could protect the striatal dopaminergic (DAergic) nerve terminals against MPTP-induced toxicity in C57BL/6N mice using immunoisolation technique for DAergic synaptosomes. CoQ
10
significantly attenuated decrease in dopamine transporter as well as in synaptophysin and actin protein levels in DAergic synaptosomes from MPTP-treated mice. The effect of CoQ
10
was also observed in crude synaptosomes fraction, but not in homogenate. Our results indicate that the nerve terminals are a site for the action of CoQ
10
against the MPTP-induced DAergic neurodegeneration.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>21598008</pmid><doi>10.1007/s10072-011-0627-z</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Neurological sciences, 2012-02, Vol.33 (1), p.195-199 |
| issn | 1590-1874 1590-3478 |
| language | eng |
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| source | Springer Nature |
| subjects | Animals Brief Communication Corpus Striatum - drug effects Corpus Striatum - pathology Dopaminergic Neurons - drug effects Dopaminergic Neurons - pathology Male Medicine Medicine & Public Health Mice MPTP Poisoning - drug therapy MPTP Poisoning - pathology Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neuroradiology Neurosurgery Psychiatry Ubiquinone - pharmacology Ubiquinone - therapeutic use |
| title | Oral administration of coenzyme Q10 reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice |
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