SPE of Tanshinones from Salvia miltiorrhiza Bunge by using Imprinted Functionalized Ionic Liquid-Modified Silica

Ionic liquid-modified silica, with functional groups based on imidazole as the cation, was obtained. A molecular imprinting technique was introduced to form the order of functional groups. The selectivity of the obtained ionic liquid-modified silica was successfully used as a special imprinted sorbe...

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Bibliographic Details
Published in:Chromatographia 2011, Vol.73 (1-2), p.25-31
Main Authors: Tian, Minglei, Row, Kyung Ho
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biological and medical sciences
Chemistry
Chemistry and Materials Science
Chromatography
Column liquid chromatography
Food industries
Fundamental and applied biological sciences. Psychology
General pharmacology
Laboratory Medicine
Medical sciences
Molecular imprinted ionic liquid-modified silica
Non alcoholic beverage industries and mineral waters
Original
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Pharmacy
Proteomics
Salvia miltiorrhiza Bunge
solid phase extraction
Tanshinones
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Summary:Ionic liquid-modified silica, with functional groups based on imidazole as the cation, was obtained. A molecular imprinting technique was introduced to form the order of functional groups. The selectivity of the obtained ionic liquid-modified silica was successfully used as a special imprinted sorbent in the solid-phase extraction to isolate cryptotanshinone, tanshinone I and tanshinone IIA from Salvia miltiorrhiza Bunge. Several washing and elution solvents with different polarities were evaluated. The ionic liquid-modified silica as the sorbent exhibited a higher selectivity than blank ionic liquid-modified silica, traditional silica and C₁₈ cartridges. A quantitative analysis was conducted by liquid chromatography with a C₁₈ column and methanol/water (75:25, v/v, containing 0.5% acetic acid) as the mobile phase. A good linearity was obtained from 0.5 × 10⁻⁴ to 0.1 mg mL⁻¹ (r ² > 0.99) with relative standard deviations that were less than 4.6%.
ISSN:0009-5893
1612-1112
DOI:10.1007/s10337-010-1836-y