Subungual acrolentiginous amelanotic melanoma treated with amputation of the distal and middle phalanges

Summary Acral lentiginous melanoma (ALM) is an uncommon melanoma type among Caucasions. ALM bears an unfavorable prognosis because of late presentation or common misdiagnosis. Amelanotic variants, albeit rare, may pose an additional clinical challenge and may further delay the diagnosis and treatmen...

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Bibliographic Details
Published in:Wiener medizinische Wochenschrift 2013-08, Vol.163 (15-16), p.368-371
Main Authors: Guarneri, Claudio, Bevelacqua, Valentina, Semkova, Kristina, Tchernev, Georgi, Tempel, Sven, Wollina, Uwe
Format: Article
Language:English
Subjects:
Amputation
Antineoplastic Agents - therapeutic use
Chemotherapy, Adjuvant
Combined Modality Therapy
Dose-Response Relationship, Drug
Family Medicine
Fingers - pathology
Fingers - surgery
General Practice
Geriatrics/Gerontology
Humans
Infectious Diseases
Interferon-alpha - therapeutic use
Internal Medicine
Main Topic
Medicine
Medicine & Public Health
Melanoma, Amelanotic - drug therapy
Melanoma, Amelanotic - pathology
Melanoma, Amelanotic - surgery
Nail Diseases - drug therapy
Nail Diseases - pathology
Nail Diseases - surgery
Neoplasm Staging
Pharmacology/Toxicology
Prognosis
Recombinant Proteins - therapeutic use
Skin Neoplasms - drug therapy
Skin Neoplasms - mortality
Skin Neoplasms - pathology
Skin Neoplasms - surgery
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Summary:Summary Acral lentiginous melanoma (ALM) is an uncommon melanoma type among Caucasions. ALM bears an unfavorable prognosis because of late presentation or common misdiagnosis. Amelanotic variants, albeit rare, may pose an additional clinical challenge and may further delay the diagnosis and treatment. Thus, the threshold for biopsying even marginally suspicious lesions should be low. We present two cases of Caucasian patients with amelanotic subungual ALM, stage 2a and 2c respectively, successfully treated with a functional amputation.
ISSN:0043-5341
1563-258X
DOI:10.1007/s10354-013-0194-4