Interplay of drug metabolizing enzymes with cellular transporters

Summary Many endogenous and xenobiotic substances and their metabolites are substrates for drug metabolizing enzymes and cellular transporters. These proteins may not only contribute to bioavailability of molecules but also to uptake into organs and, consequently, to overall elimination. The coordin...

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Bibliographic Details
Published in:Wiener medizinische Wochenschrift 2014-11, Vol.164 (21-22), p.461-471
Main Authors: Böhmdorfer, Michaela, Maier-Salamon, Alexandra, Riha, Juliane, Brenner, Stefan, Höferl, Martina, Jäger, Walter
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - adverse effects
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological Transport - genetics
Biological Transport - physiology
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - enzymology
Drug Resistance, Neoplasm - genetics
Drug Resistance, Neoplasm - physiology
Enzymes - blood
Enzymes - genetics
Family Medicine
General Practice
Geriatrics/Gerontology
Humans
Infectious Diseases
Internal Medicine
Liver Neoplasms - drug therapy
Liver Neoplasms - enzymology
Liver Neoplasms - genetics
Medicine
Medicine & Public Health
Pharmacology/Toxicology
Rats
Rats, Wistar
Review
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Summary:Summary Many endogenous and xenobiotic substances and their metabolites are substrates for drug metabolizing enzymes and cellular transporters. These proteins may not only contribute to bioavailability of molecules but also to uptake into organs and, consequently, to overall elimination. The coordinated action of uptake transporters, metabolizing enzymes, and efflux pumps, therefore, is a precondition for detoxification and elimination of drugs. As the understanding of the underlying mechanisms is important to predict alterations in drug disposal, adverse drug reactions and, finally, drug–drug interactions, this review illustrates the interplay between selected uptake/efflux transporters and phase I/II metabolizing enzymes.
ISSN:0043-5341
1563-258X
DOI:10.1007/s10354-014-0301-1