Effect of NO synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine on endotoxin-induced changes in hemodynamic parameters and respiration in rats

• Published in: Bulletin of experimental biology and medicine 2004-10, Vol.138 (4), p.397-400
• Main Authors: Proskuryakov, S Ya, Filimonova, M V, Verkhovskii, Yu G, Konoplyannikov, A G, Mandrugin, A A, Fedoseev, V M, Skvortsov, V G
• Format: Article
• Language: English
• Subjects: Animals; Dose-Response Relationship, Drug; Endotoxins - toxicity; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - toxicity; Heart Rate - drug effects; Hemodynamics - drug effects; Male; Nitric Oxide Synthase - antagonists & inhibitors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Respiration - drug effects; Shock, Septic - drug therapy; Shock, Septic - physiopathology; Thiazines - administration & dosage; Thiazines - pharmacology; Thiazines - toxicity
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-005-0110-z

We studied the effect of NO synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine (2-ADT) on the cardiovascular system in rats with endotoxic shock. Blood pressure, heart rate, and respiratory rate were recorded. E. coli lipopolysaccharide decreased blood pressure and heart rate. 2-ADT in a dose of 5 mg/kg normalized these hemodynamic parameters. The normalizing effect of 2-ADT decreased with increasing the dose of this preparation. 2-ADT in high doses (10, 20, and 30 mg/kg) and repeated injections of the preparation caused death of experimental animals.