Effects of ⁶⁰Co whole-body γ-irradiation in different doses on the distribution of ¹⁸⁸Re-labeled autologous mesenchymal stem cells in Wistar rats after intravenous (systemic) transplantation during different periods after exposure

• Published in: Bulletin of experimental biology and medicine 2008, Vol.145 (4), p.520-525
• Main Authors: Konoplyannikov, A. G, Petriev, V. M, Konoplyannikova, O. A, Kal'sina, S. Sh, Lepechina, L. A, Smorizanova, O. A, Semenkova, I. V, Agaeva, E. V
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Biomedicine; Cell Biology; Co γ-irradiation; Internal Medicine; Laboratory Medicine; mesenchymal stem cells; Pathology; rats; Re; stem cell homing; systemic cell transplantation; Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-008-0132-4

The effects of whole-body γ-irradiation in different doses on the distribution of ¹⁸⁸Re-labeled mesenchymal stem cells obtained by culturing of the rat bone marrow cells were studied in different organs and tissues of animals after intravenous (systemic) injection. Irradiation stimulated homing of ¹⁸⁸Re-labeled mesenchymal stem cells in organs and tissues of animals in comparison with this process in intact non-irradiated rats. The intensity of homing increased with increasing the irradiation dose and decreased with prolongation of the period between irradiation and systemic transplantation. It was hypothesized that increased migration of transplanted mesenchymal stem cells into irradiated organs and tissues can be caused by developing cell death processes. It seems that systemic transplantation of mesenchymal stem cells shortly after irradiation can be used for stimulation of reparative processes in damaged tissues.