Effect of 5-HT2A Receptor Antagonists on Blood Flow in the Carotid Vessels upon Elevation of Serotonin Level

We studied the ability of predominantly 5-HT 2A receptor antagonists to prevent a serotonin-induced change of blood flow in the carotid vessels of rats with experimental serotonin-induced spasm. Ritanserin, ketanserin, and 5-HT 2A receptor antagonist RU-476 reduced the effect of serotonin on the blo...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-07, Vol.157 (3), p.350-352
Main Authors: Yakovlev, D. S., Spasov, A. A., Mal’tsev, D. V., Anisimova, V. A.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Laboratory Medicine
Pathology
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Summary:We studied the ability of predominantly 5-HT 2A receptor antagonists to prevent a serotonin-induced change of blood flow in the carotid vessels of rats with experimental serotonin-induced spasm. Ritanserin, ketanserin, and 5-HT 2A receptor antagonist RU-476 reduced the effect of serotonin on the blood fl ow velocity in the internal carotid artery by 2.3, 1.7, and 2.6 times, respectively.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2563-4