A Polymorphism Within the 3′UTR of NLRP3 is Associated with Susceptibility for Ischemic Stroke in Chinese Population

Stroke was regarded as a severe disorder with high morbidity and high mortality worldwide, ischemic stroke (IS) accounts for 85 to 90 % of new increased stroke cases. Partial mechanisms were elucidated by genetic factors including genomic instability such as single nucleotide polymorphism (SNP). Pre...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2016-08, Vol.36 (6), p.981-988
Main Authors: Zhu, Zhansheng, Yan, Jing, Geng, Chunsong, Wang, Dagang, Li, Chaoyang, Feng, Shuai, Wang, Huiping
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Neurobiology
Neurosciences
Original Research
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Summary:Stroke was regarded as a severe disorder with high morbidity and high mortality worldwide, ischemic stroke (IS) accounts for 85 to 90 % of new increased stroke cases. Partial mechanisms were elucidated by genetic factors including genomic instability such as single nucleotide polymorphism (SNP). Previous reports demonstrated that inflammation was involved in IS, NLRP3 [nucleotide-binding domain (NOD)-like receptor protein 3], acting as a specific inflammatory gene, however, its function and influence on IS was not well clarified. In this study, a case–control study including 1102 IS patients and 1610 healthy controls was conducted to investigate the association between IS susceptibility with a SNP (rs10754558) in 3′UTR of NLRP3 . Logistic regression analysis showed that the heterozygote and the homozygote GG confer a significantly increased risk of CRC after controlling for other covariates (adjusted OR = 1.52, 95 % C.I. 1.19–1.97, P  = 0.002; adjusted OR = 2.22, 95 % C.I. 2.18–3.67, P  
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-015-0288-1