Polyfunctional nitriles in the synthesis of derivatives of 1,3,4-thiadiazolo-[3,2-a]pyrimidines

A one-pot method has been developed for the synthesis of 2-R-7-methyl-5-oxo-5H-1,3,4-thia-diazolo[3,2-a]pyrimidine by condensation of β-alkylthio(alkoxy)propionitrile, thiosemicarbazide, and ethyl acetoacetate in PPA, and also (7-methyl-5-oxo-5H-1,3,4-thidiazolo[3,2-a]pyrimidin-2-yl)-acetamide from...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2008-07, Vol.44 (7), p.882-885
Main Authors: Kukaniev, M. A., Osimov, M. D., Sangov, Z. G., Safarov, S. S., Karimov, M. B., Radjabov, T. R.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
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Summary:A one-pot method has been developed for the synthesis of 2-R-7-methyl-5-oxo-5H-1,3,4-thia-diazolo[3,2-a]pyrimidine by condensation of β-alkylthio(alkoxy)propionitrile, thiosemicarbazide, and ethyl acetoacetate in PPA, and also (7-methyl-5-oxo-5H-1,3,4-thidiazolo[3,2-a]pyrimidin-2-yl)-acetamide from cyanoacetamide, thiosemicarbazide, and ethyl acetoacetate.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-008-0125-2