Synthesis and reactions of 5-aryl-2-thiophenecarbaldehydes

The reaction of 2-thiophenecarbaldehyde with arene diazonium chlorides in the presence of CuCl 2 catalyst gave 5-aryl-2-thiophenecarbaldehydes. Use of 4-nitrobenzene diazonium chloride in the reaction also gave the isomeric 3-(4-nitrophenyl)-2-thiophenecarbaldehyde. Condensation products of the 5-ar...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2008-08, Vol.44 (8), p.936-940
Main Authors: Obushak, M. D., Matiychuk, V. S., Lytvyn, R. Z.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
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Summary:The reaction of 2-thiophenecarbaldehyde with arene diazonium chlorides in the presence of CuCl 2 catalyst gave 5-aryl-2-thiophenecarbaldehydes. Use of 4-nitrobenzene diazonium chloride in the reaction also gave the isomeric 3-(4-nitrophenyl)-2-thiophenecarbaldehyde. Condensation products of the 5-aryl-2-thiophenecarbaldehydes with cyanoacetic acid esters, cyanoacetamide, and with barbituric and dimethylbarbituric acids were prepared.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-008-0135-0