Synthesis of novel [1-aziridinyl-(hydroxyimino)methyl]arenes and their cytotoxic activity

The synthesis has been developed for novel potential anticancer agents whose structures contain an aziridine amidoxime group. The cytotoxic activity of all of the target compounds on different cell lines are given together with the in vitro IC₅₀ and LD₅₀ values found. The most promising anticancer a...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2009-02, Vol.45 (2), p.161-168
Main Authors: Grigorjeva, A, Jirgensons, A, Domracheva, I, Yashchenko, E, Shestakova, I, Andrianov, V, Kalvinsh, I
Format: Article
Language:English
Subjects:
amidoximes
aziridine
Chemistry
Chemistry and Materials Science
cytotoxic activity
hydroxyimidoyl chlorides
Organic Chemistry
oximes
Pharmacy
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Summary:The synthesis has been developed for novel potential anticancer agents whose structures contain an aziridine amidoxime group. The cytotoxic activity of all of the target compounds on different cell lines are given together with the in vitro IC₅₀ and LD₅₀ values found. The most promising anticancer agents were found to be the methyl 4-[1-aziridinyl(hydroxyimino)methyl]benzoate, 1-aziridinyl(2-naphthyl)-methanone oxime, and 1-aziridinyl(2-quinolyl)methanone oxime.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-009-0245-3