Synthesis of norbornane series tetra- and hexahydropyrimidines

Condensation of exo -2-amino- exo -3-aminomethylnorbornane with acetone, methyl cyclopropyl ketone, cyclohexanone, urea, and formic, acetic, and benzoic acids gave norbornane series tetra- and hexa-hydropyrimidines. It was found that 4-cyclopropyl-4-methyl- exo -3,5-diazatricyclo[6.2.1.0 2,7 ]undeca...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2009-06, Vol.45 (6), p.685-690
Main Authors: Shafikova, E. A., Petrov, D. V., Sapozhnikova, T. A., Baschenko, N. J., Dokichev, V. A.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
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Summary:Condensation of exo -2-amino- exo -3-aminomethylnorbornane with acetone, methyl cyclopropyl ketone, cyclohexanone, urea, and formic, acetic, and benzoic acids gave norbornane series tetra- and hexa-hydropyrimidines. It was found that 4-cyclopropyl-4-methyl- exo -3,5-diazatricyclo[6.2.1.0 2,7 ]undecane and 4-methyl-exo-3,5-diazatricyclo[6.2.1.0 2,7 ]undec-3-ene show analgesic activity.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-009-0328-1