Synthesis, thermal transformations, and mass spectrometric fragmentation of 4,4'-[1,2-bis(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)ethane-1,2-diyl]-bis(5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one)

Quinoxaline reacted with 3-methyl-1-phenylpyrazol-5-one at room temperature in the presence of triethylamine in DMSO solution, to form 4,4'-[1,2-bis(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-ethane-1,2-diyl]bis(5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one). Heating of the obtained crystall...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2013-07, Vol.49 (4), p.545-550
Main Authors: Azev, Yu. A., Kovalev, I. S., Mekhaev, A. V., Gibor, A. M., Baranov, V. I., Bakulev, V. A., Ermakova, O. S.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
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Summary:Quinoxaline reacted with 3-methyl-1-phenylpyrazol-5-one at room temperature in the presence of triethylamine in DMSO solution, to form 4,4'-[1,2-bis(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-ethane-1,2-diyl]bis(5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one). Heating of the obtained crystalline product at 240-250°C temperature led to the known 4-[(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylidene]-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one. The mass spectral fragmentation of the obtained compounds was characterized.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-013-1280-7