Synthesis of 2,5-Dihydroisothiazole Derivatives. 2. 3-Aryl(Hetaryl)-Substituted 2-Alkyl-5-Arylimino-2,5-Dihydroisothiazoles

A series of new 2-alkyl-5-arylimino-2,5-dihydroisothiazoles, substituted at position 3 with aryl and hetaryl groups and not substituted at position 4 was prepared by oxidative cyclization of N -arylamides of 3-alkylaminoprop-2-enethioic acids. The formation of the starting thioanilides was investiga...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2014-04, Vol.50 (1), p.87-102
Main Authors: Skrastiņa, I., Baran, A., Muceniece, D., Popelis, J.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
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Summary:A series of new 2-alkyl-5-arylimino-2,5-dihydroisothiazoles, substituted at position 3 with aryl and hetaryl groups and not substituted at position 4 was prepared by oxidative cyclization of N -arylamides of 3-alkylaminoprop-2-enethioic acids. The formation of the starting thioanilides was investigated by reacting the respective N -alkylimines of acetophenones with isothiocyanates. The main by-products were identified and characterized.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-014-1451-1