novel compound from Flos carthami and its bioactivity

A novel compound, 4-{1'-hydroxy-1'-mercapto-1'-[1''-2''(N[rightward arrow]O)-isoquinolyl]}yl-1-benzoic acid (1), together with six known compounds, 6-hydroxykaempferol-3-O-β-D-glucopyranoside (2), rutin (3), quercetin-3-O-β-D-glucopyranoside (4), kaempferol-3-O-β-D...

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Bibliographic Details
Published in:Chemistry of natural compounds 2009, Vol.45 (3), p.398-401
Main Authors: Zhang, Ge, Guo, Mei-Li, Li, Run-Ping, Li, Ying, Zhang, Han-Ming, Su, Zhong-Wu
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
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Summary:A novel compound, 4-{1'-hydroxy-1'-mercapto-1'-[1''-2''(N[rightward arrow]O)-isoquinolyl]}yl-1-benzoic acid (1), together with six known compounds, 6-hydroxykaempferol-3-O-β-D-glucopyranoside (2), rutin (3), quercetin-3-O-β-D-glucopyranoside (4), kaempferol-3-O-β-D-glucopyranoside (5), cartormin (6), hydroxysafflor yellow A (7), were isolated by chromatography from the n-BuOH fraction of 50% ethanol extraction of Flos carthami. Their structures were elucidated on the basis of spectral analysis and comparison with published data. Among them, compound 1 was shown to possess a weak protective effect against cerebral ischemic damage in rats.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-009-9333-y