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Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats
Objective To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. Methods Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days...
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| Published in: | Inflammopharmacology 2019-04, Vol.27 (2), p.313-322 |
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| container_title | Inflammopharmacology |
| container_volume | 27 |
| creator | Tekeli, İbrahim Ozan Ateşşahin, Ahmet Sakin, Fatih Aslan, Abdullah Çeribaşı, Songül Yipel, Mustafa |
| description | Objective
To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats.
Methods
Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochemical and histopathological analysis.
Results
Malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased (
p |
| doi_str_mv | 10.1007/s10787-018-0485-x |
| format | article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_s10787_018_0485_x</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>29736689</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-b6b75a9852402f9006df6592a80219238ff9e7d85f949d5ec9b895439e5147fb3</originalsourceid><addsrcrecordid>eNp9kM1OAyEURonR2Fp9ADeGF0CBGRhYmsa_xEQXup4wzKXBjNDAtGl3PrroqEtXl9z7nS_hIHTO6CWjtLnKjDaqIZQpQmslyO4AzZmQighJ1SGaU80FqaXmM3SS8xulVDZSH6MZ100lpdJz9PGc4gh29FvA4Fx5ZRwdtjFsIYw-BjNgE_qyGGIgo0krGKHHw97GNQT4vg2-pGIccAx4M1hI5ruuIH70GfvQb2xhuj02FkZvy_B9WeMSzKfoyJkhw9nPXKDX25uX5T15fLp7WF4_ElvV9Ug62TXCaCV4TbnT5Se9k0JzoyhnmlfKOQ1Nr4TTte4FWN0pLepKg2B147pqgdjUa1PMOYFr18m_m7RvGW2_bLaTzbbYbL9strvCXEzMetO9Q_9H_OorAT4FcjmFFaT2LW5SsZH_af0E59OCyA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats</title><source>Springer Link</source><creator>Tekeli, İbrahim Ozan ; Ateşşahin, Ahmet ; Sakin, Fatih ; Aslan, Abdullah ; Çeribaşı, Songül ; Yipel, Mustafa</creator><creatorcontrib>Tekeli, İbrahim Ozan ; Ateşşahin, Ahmet ; Sakin, Fatih ; Aslan, Abdullah ; Çeribaşı, Songül ; Yipel, Mustafa</creatorcontrib><description><![CDATA[Objective
To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats.
Methods
Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochemical and histopathological analysis.
Results
Malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased (
p
< 0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (
p
< 0.05). Tumor necrosis factor α (TNF-α) level was also decreased (
p
< 0.05) and catalase activity (CAT) was increased (
p
< 0.05) in the TLC group compared to the AA group. IL-1β and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (
p
< 0.05). COX-2 and NF-κB levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (
p
< 0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (
p
< 0.05).
Conclusion
As expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further.]]></description><identifier>ISSN: 0925-4692</identifier><identifier>EISSN: 1568-5608</identifier><identifier>DOI: 10.1007/s10787-018-0485-x</identifier><identifier>PMID: 29736689</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Allergology ; Biomedical and Life Sciences ; Biomedicine ; Dermatology ; Gastroenterology ; Immunology ; Original Article ; Pharmacology/Toxicology ; Rheumatology</subject><ispartof>Inflammopharmacology, 2019-04, Vol.27 (2), p.313-322</ispartof><rights>Springer International Publishing AG, part of Springer Nature 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-b6b75a9852402f9006df6592a80219238ff9e7d85f949d5ec9b895439e5147fb3</citedby><cites>FETCH-LOGICAL-c344t-b6b75a9852402f9006df6592a80219238ff9e7d85f949d5ec9b895439e5147fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29736689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tekeli, İbrahim Ozan</creatorcontrib><creatorcontrib>Ateşşahin, Ahmet</creatorcontrib><creatorcontrib>Sakin, Fatih</creatorcontrib><creatorcontrib>Aslan, Abdullah</creatorcontrib><creatorcontrib>Çeribaşı, Songül</creatorcontrib><creatorcontrib>Yipel, Mustafa</creatorcontrib><title>Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats</title><title>Inflammopharmacology</title><addtitle>Inflammopharmacol</addtitle><addtitle>Inflammopharmacology</addtitle><description><![CDATA[Objective
To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats.
Methods
Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochemical and histopathological analysis.
Results
Malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased (
p
< 0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (
p
< 0.05). Tumor necrosis factor α (TNF-α) level was also decreased (
p
< 0.05) and catalase activity (CAT) was increased (
p
< 0.05) in the TLC group compared to the AA group. IL-1β and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (
p
< 0.05). COX-2 and NF-κB levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (
p
< 0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (
p
< 0.05).
Conclusion
As expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further.]]></description><subject>Allergology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Dermatology</subject><subject>Gastroenterology</subject><subject>Immunology</subject><subject>Original Article</subject><subject>Pharmacology/Toxicology</subject><subject>Rheumatology</subject><issn>0925-4692</issn><issn>1568-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kM1OAyEURonR2Fp9ADeGF0CBGRhYmsa_xEQXup4wzKXBjNDAtGl3PrroqEtXl9z7nS_hIHTO6CWjtLnKjDaqIZQpQmslyO4AzZmQighJ1SGaU80FqaXmM3SS8xulVDZSH6MZ100lpdJz9PGc4gh29FvA4Fx5ZRwdtjFsIYw-BjNgE_qyGGIgo0krGKHHw97GNQT4vg2-pGIccAx4M1hI5ruuIH70GfvQb2xhuj02FkZvy_B9WeMSzKfoyJkhw9nPXKDX25uX5T15fLp7WF4_ElvV9Ug62TXCaCV4TbnT5Se9k0JzoyhnmlfKOQ1Nr4TTte4FWN0pLepKg2B147pqgdjUa1PMOYFr18m_m7RvGW2_bLaTzbbYbL9strvCXEzMetO9Q_9H_OorAT4FcjmFFaT2LW5SsZH_af0E59OCyA</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Tekeli, İbrahim Ozan</creator><creator>Ateşşahin, Ahmet</creator><creator>Sakin, Fatih</creator><creator>Aslan, Abdullah</creator><creator>Çeribaşı, Songül</creator><creator>Yipel, Mustafa</creator><general>Springer International Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20190401</creationdate><title>Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats</title><author>Tekeli, İbrahim Ozan ; Ateşşahin, Ahmet ; Sakin, Fatih ; Aslan, Abdullah ; Çeribaşı, Songül ; Yipel, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-b6b75a9852402f9006df6592a80219238ff9e7d85f949d5ec9b895439e5147fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Allergology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Dermatology</topic><topic>Gastroenterology</topic><topic>Immunology</topic><topic>Original Article</topic><topic>Pharmacology/Toxicology</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tekeli, İbrahim Ozan</creatorcontrib><creatorcontrib>Ateşşahin, Ahmet</creatorcontrib><creatorcontrib>Sakin, Fatih</creatorcontrib><creatorcontrib>Aslan, Abdullah</creatorcontrib><creatorcontrib>Çeribaşı, Songül</creatorcontrib><creatorcontrib>Yipel, Mustafa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Inflammopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tekeli, İbrahim Ozan</au><au>Ateşşahin, Ahmet</au><au>Sakin, Fatih</au><au>Aslan, Abdullah</au><au>Çeribaşı, Songül</au><au>Yipel, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats</atitle><jtitle>Inflammopharmacology</jtitle><stitle>Inflammopharmacol</stitle><addtitle>Inflammopharmacology</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>27</volume><issue>2</issue><spage>313</spage><epage>322</epage><pages>313-322</pages><issn>0925-4692</issn><eissn>1568-5608</eissn><abstract><![CDATA[Objective
To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats.
Methods
Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochemical and histopathological analysis.
Results
Malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased (
p
< 0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (
p
< 0.05). Tumor necrosis factor α (TNF-α) level was also decreased (
p
< 0.05) and catalase activity (CAT) was increased (
p
< 0.05) in the TLC group compared to the AA group. IL-1β and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (
p
< 0.05). COX-2 and NF-κB levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (
p
< 0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (
p
< 0.05).
Conclusion
As expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further.]]></abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29736689</pmid><doi>10.1007/s10787-018-0485-x</doi><tpages>10</tpages></addata></record> |
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| subjects | Allergology Biomedical and Life Sciences Biomedicine Dermatology Gastroenterology Immunology Original Article Pharmacology/Toxicology Rheumatology |
| title | Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats |
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