Crystal structures of alkaloid peganine and its cocrystal with peganol

X-ray diffraction (XRD) is used to investigate the crystal structures of the alkaloid peganine, its hemihydrate and nitrate. It is shown that (±)-peganine forms a cocrystal with the alkaloid peganol. It is typical of the alkaloid (−)-peganine crystal structures to form a closed dimer pair because of...

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Bibliographic Details
Published in:Journal of structural chemistry 2009-12, Vol.50 (6), p.1149-1154
Main Authors: Okmanov, R. Ya, Tozhiboev, A. G., Turgunov, K. K., Tashkhodzhaev, B., Khakimova, Z. M., Tulyaganov, T. S., Shakhidoyatov, Kh. M.
Format: Article
Language:English
Subjects:
Atomic
Atomic/Molecular Structure and Spectra
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Molecular
Optical and Plasma Physics
Physical Chemistry
Solid State Physics
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Summary:X-ray diffraction (XRD) is used to investigate the crystal structures of the alkaloid peganine, its hemihydrate and nitrate. It is shown that (±)-peganine forms a cocrystal with the alkaloid peganol. It is typical of the alkaloid (−)-peganine crystal structures to form a closed dimer pair because of reciprocal O-H⋯N1 hydrogen bonds. Analogous H-bonds are also observed in the (±)-peganine-(±)-peganol cocrystal, where the center of symmetry binds together similar molecules to form associates. In (±)-peganine nitrate crystals, the NH + and OH groups of the alkaloid form H-bonds simultaneously with two oxygen atoms of nitric acid anions.
ISSN:0022-4766
1573-8779
DOI:10.1007/s10947-009-0168-y