A convenient method for 14C-labeling of N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-1H-pyrrole-2-carboxamide-[carboxy-14C] as CCK-A antagonist

N -(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-1H-pyrrole-2-carboxamide-[carboxy- 14 C] was prepared as part of a five-step sequence from pyrrol-2-carbonitrile-[cyano- 14 C] as a key synthetic intermediate which has been synthesized from 2-bromopyrrole and zinc [ 14 C]-cyanide in the...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2012-04, Vol.292 (1), p.119-122
Main Authors: Saemian, Nader, Shirvani, Gholamhossein
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Hadrons
Heavy Ions
Inorganic Chemistry
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
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Summary:N -(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-1H-pyrrole-2-carboxamide-[carboxy- 14 C] was prepared as part of a five-step sequence from pyrrol-2-carbonitrile-[cyano- 14 C] as a key synthetic intermediate which has been synthesized from 2-bromopyrrole and zinc [ 14 C]-cyanide in the presence of tetrakis (triphenylphosphine)palladium.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-011-1378-2