Polymorphic effects at the eutectic melting in the H2O–glycine system

Solid mixtures of ice with three glycine polymorphs were heated up to the eutectic melting and the DSC has detected the eutectic temperatures of −2.8 °C for α-, −3.6 °C for β-, and −2.8 °C for γ-glycine. DSC peaks of the eutectic melting are rather strange in shape, indicating unclear processes in t...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2013-03, Vol.111 (3), p.2187-2194
Main Authors: Drebushchak, V. A., Ogienko, A. G., Boldyreva, Elena V.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Measurement Science and Instrumentation
Physical Chemistry
Polymer Sciences
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Summary:Solid mixtures of ice with three glycine polymorphs were heated up to the eutectic melting and the DSC has detected the eutectic temperatures of −2.8 °C for α-, −3.6 °C for β-, and −2.8 °C for γ-glycine. DSC peaks of the eutectic melting are rather strange in shape, indicating unclear processes in the solutions. Accurate DSC measurements of extremely small samples can probably provide us with the physicochemical tool for the investigation of polymorphic differences among different solutions. This may be important in relation to different bioavailability of solutions prepared from different polymorphs. Eutectic temperature of −4.7 °C in water–glycine system allows us to suggest that the unknown polymorph of glycine exists.
ISSN:1388-6150
1588-2926
1572-8943
DOI:10.1007/s10973-012-2761-0