Complexes of dihydroquercetin with chromium (III) and zinc (II) asparaginates in water and their effects on the state of lecithin membranes

The formation of chelate complexes of dihydroqercetin (DHQ) with zinc and chromium asparaginates in aqueous solution is established and their interaction with a lecithin monolayer is estimated. On the basis of analysis of the surface pressure-molecular area isotherms, it is concluded that an increas...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2008-10, Vol.42 (10), p.564-570
Main Authors: Donracheva, L. G, Mel'nikova, N. B, Pegova, I. A, Volkov, A. A, Domrachev, G. A, Kol'chik, O. V
Format: Article
Language:English
Subjects:
Medicine
Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:The formation of chelate complexes of dihydroqercetin (DHQ) with zinc and chromium asparaginates in aqueous solution is established and their interaction with a lecithin monolayer is estimated. On the basis of analysis of the surface pressure-molecular area isotherms, it is concluded that an increase in the molecular area from 0.54 to 0.80-0.90 nm 2 is indicative of the immobilization of DHQ complexes in the lecithin monolayer. It is shown that the concentration of the initial products of lipid peroxidacion-diene and triene conjugates-decreases to 24 % and 41 %, respectively, and that of the final products (Schiff bases) in the blood of patients treated by Oftalvit (containing DHQ and metal asparaginates) decreases to 46 % in comparison to values in the control groups.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-009-0186-2