Imidazole derivatives and their antitumor activity (review)

Bis(2-chloroethyl)amino derivatives of imidazole, 4(5)-aminoimidazol-5(4)-carboxamide, 4-nitro-5-thioimidazole, benzimidazole, and imidazolylpeptides are reviewed. Data are presented for active compounds, some of which have passed the preclinical testing stage. Structures under consideration are int...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical chemistry journal 2009-08, Vol.43 (8), p.439-443, Article 439
Main Authors: Iradyan, M. A, Iradyan, N. S, Arsenyan, F. G, Stepanyan, G. M
Format: Article
Language:English
Subjects:
4-aminoimidazol-5-carboxamide
4-nitro-5-thioimidazole
antitumor activity
benzimidazole
bis(2-chloroethyl)amino derivatives
imidazole
imidazolylpeptides
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Search for New Drugs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bis(2-chloroethyl)amino derivatives of imidazole, 4(5)-aminoimidazol-5(4)-carboxamide, 4-nitro-5-thioimidazole, benzimidazole, and imidazolylpeptides are reviewed. Data are presented for active compounds, some of which have passed the preclinical testing stage. Structures under consideration are interesting with respect to both the search for new antitumor drugs and the synthesis of compounds with different biological properties.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-009-0333-9