Synthesis and antitumor activity of 3,4,5-substituted 1,2,4-triazoles

Conditions for effective alkylation of new 3,4-substituted-5-mercapto-1,2,4-triazoles with various alkylating agents are established. Several compounds possessing pronounced antitumor activity have been found in experiments using two xenograft tumor models.

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2009-12, Vol.43 (12), p.645-648
Main Authors: Ovsepyan, T. R, Melik-Ogandzhanyan, R. G, Panosyan, G. A, Arsenyan, F. G, Garibdzhanyan, B. T
Format: Article
Language:English
Subjects:
1,2,4-triazole
antitumor activity
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
synthesis
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Description
Summary:Conditions for effective alkylation of new 3,4-substituted-5-mercapto-1,2,4-triazoles with various alkylating agents are established. Several compounds possessing pronounced antitumor activity have been found in experiments using two xenograft tumor models.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0371-3