Preparation of cation-exchange sorbent for 99mTc generator chromatographic column

A new cation-exchange sorbent based on polyethylene powder modified by polyacrylic acid was prepared for a technetium-99 m generator column. The dependence of the kinetics of polyethylene modification on the composition of the grafting solution was studied. The adsorption of manganese ions by the ob...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2011-09, Vol.45 (6), p.363-365
Main Authors: Il’icheva, N. S., Kitaeva, N. K., Duflot, V. R.
Format: Article
Language:English
Subjects:
Drug Synthesis Methods and Manufacturing Technology
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:A new cation-exchange sorbent based on polyethylene powder modified by polyacrylic acid was prepared for a technetium-99 m generator column. The dependence of the kinetics of polyethylene modification on the composition of the grafting solution was studied. The adsorption of manganese ions by the obtained sorbent has been studied. The new sorbent was tested in a technetium-99 m generator column with the maximum output activity. It is expedient to use the sorbent in a technetium-99 m generator column in order to improve the quality of the effluent, increase the consistency of the yield of pertechnetate ions, and maintain the eluate medium in a condition close to neutral.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0634-7