Synthesis and antibacterial and antifungal properties of 2-thiocyanato-(2-methyl)-3-arylpropionamides and 2-amino-5-benzyl-(5-methyl)thiazol-4-ones

A series of 2-thiocyanato-(2-methyl)-3-arylpropionamides and products of their heterocyclization, 2-amino-5-benzyl-(5-methyl)thiazol-4-ones, have been synthesized. The synthesized compounds exhibit rather high antibacterial activity with respect to strains of staphylococci, intestinal rods, aerobic...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2011-11, Vol.45 (9), p.532-535
Main Authors: Grishchuk, B. D., Baranovskii, V. S., Klimnyuk, S. I.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:A series of 2-thiocyanato-(2-methyl)-3-arylpropionamides and products of their heterocyclization, 2-amino-5-benzyl-(5-methyl)thiazol-4-ones, have been synthesized. The synthesized compounds exhibit rather high antibacterial activity with respect to strains of staphylococci, intestinal rods, aerobic bacilli, and yeast fungi. The majority of these compounds show a clearly expressed anti-candidiasis effect.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0673-0