Synthesis of pyrimidylhydrazones and substituted pyrimidyl-aryl- and –yclohexylthiosemicarbazides and study of their influence on DNA methylation

Reactions of 4,6-dihydrazino-5-nitro- and 2-methylthio-4-hydrazino-6-chloro-5-( p -alkoxybenzyl)pyrimidines with carbonyl compounds and aryl- and cyclohexylisothiocyanates were studied. The influence of the products on DNA methylation and their in vitro antitumor properties were studied.

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2012-10, Vol.46 (7), p.402-405
Main Authors: Grigoryan, L. A., Kaldrikyan, M. A., Melik-Ogandzhanyan, R. G., Garibyan, J. V., Nersesyan, L. E., Agaronyan, A. S.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:Reactions of 4,6-dihydrazino-5-nitro- and 2-methylthio-4-hydrazino-6-chloro-5-( p -alkoxybenzyl)pyrimidines with carbonyl compounds and aryl- and cyclohexylisothiocyanates were studied. The influence of the products on DNA methylation and their in vitro antitumor properties were studied.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-012-0809-x