Synthesis and pharmacological activity of 3-(n,n-disubstituted)acetamide-1-r-2-aminobenzimidazolium chlorides

A series of 3-( N , N -disubstituted)acetamide-1- R -2-aminobenzimidazolium chlorides were synthesized. Their pharmacological properties were studied. It was established that the synthesized substances decreased platelet aggregation and possessed antioxidant and antiarrhythmic activity. Some of the...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2012-12, Vol.46 (9), p.526-530
Main Authors: Anisimova, V. A., Spasov, A. A., Kosolapov, V. A., Tolpygin, I. E., El’tsova, L. V., Kucheryavenko, A. F., Naumenko, L. V., Gurova, N. A., Lenskaya, K. V., Yakovlev, D. S., Mal’tsev, D. V., Mitina, T. M., Grechko, O. Yu
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:A series of 3-( N , N -disubstituted)acetamide-1- R -2-aminobenzimidazolium chlorides were synthesized. Their pharmacological properties were studied. It was established that the synthesized substances decreased platelet aggregation and possessed antioxidant and antiarrhythmic activity. Some of the compounds produced a hypoglycemic action and exhibited antagonistic activity with respect to serotonin 5-HT 2 receptors.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-012-0839-4