Synthesis of 16β-Methylpregn-4,9(11)-Diene-17α-Ol-3,20-Dione From 9α-Hydroxyandrostenedione

An efficient synthesis of 16β-methyl-pregn-4,9(11)-diene-17α-ol-3,20-dione from 9α-hydroxyandrostenedione via its ∆ 9 -analog has been developed. Structure of the product and its intermediates were examined by spectral methods including IR spectroscopy, mass spectrometry, and 1D and 2D NMR technique...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2015-10, Vol.49 (7), p.486-489
Main Authors: Huy, Luu D., Diep, Nguyen T.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:An efficient synthesis of 16β-methyl-pregn-4,9(11)-diene-17α-ol-3,20-dione from 9α-hydroxyandrostenedione via its ∆ 9 -analog has been developed. Structure of the product and its intermediates were examined by spectral methods including IR spectroscopy, mass spectrometry, and 1D and 2D NMR techniques.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-015-1311-z