Formulation Development and Study of Prolonged Release from Amben Peroral Preparations Based on Hydrophobic Matrices

Results from research on formulation development and prolonged release of peroral 4-aminomethylbenzoic acid (amben) using hydrophobic lipid and polymer matrices are reported. It is shown that the amben release parameters considering its solubility at various pH values can be achieved by using the st...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2016-05, Vol.50 (2), p.90-95
Main Authors: Nifontova, G. O., Dolotova, O. V., Sarantseva, I. V., Akhmetzyanova, A. R., Krechetov, S. P., Krasnyuk, I. I.
Format: Article
Language:English
Subjects:
Drug Synthesis Methods and Manufacturing Technology
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:Results from research on formulation development and prolonged release of peroral 4-aminomethylbenzoic acid (amben) using hydrophobic lipid and polymer matrices are reported. It is shown that the amben release parameters considering its solubility at various pH values can be achieved by using the studied polymer hydrophobic matrices.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1404-3