Casette Dosing for Optimization of Toxico(pharmaco)kinetic Investigations

The need to screen the kinetic characteristics of pharmaceuticals in early development stages is justified. The advantages and limitations of cassette dosing in pharmacokinetic investigations are discussed. The dose and the presence or absence of pharmaceutical interactions are shown to be the criti...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2016-11, Vol.50 (8), p.548-552
Main Authors: Savel’eva, E. I., Sorokoumov, P. N., Orlova, O. I., Koryagina, N. L.
Format: Article
Language:English
Subjects:
Medicine
Methods of Analysis and Process Control
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Structure of Chemical Compounds
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Summary:The need to screen the kinetic characteristics of pharmaceuticals in early development stages is justified. The advantages and limitations of cassette dosing in pharmacokinetic investigations are discussed. The dose and the presence or absence of pharmaceutical interactions are shown to be the critical factors affecting the reliability of pharmacokinetic parameters assessed by the cassette method. The hypothesis that toxicokinetic cassette screening of compounds capable of interacting is appropriate for describing the slow elimination phase was verified by comparing lewisite excretion parameters after injection into laboratory animals of lewisite and a mustard-gas—lewisite mixture.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1487-x