Synthesis and Pharmacological Properties of the Azo-Conjugate of Erythropoietin β with Poly(Ethylene Glycol)

A conjugate of erythropoietin β with 30 kDa linear methoxy poly(ethylene glycol) characterized by the presence of an azo spacer between the protein fragment and poly(ethylene glycol) was developed for import-substitution of Mircera drug in the Russian Federation. The erythropoietic activity of the s...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2021-10, Vol.55 (7), p.698-705
Main Authors: Sheremet’ev, S. V., Lonshakov, D. V., Belosludtseva, E. M., Borisova, O. V., Sidorova, A. V., Kalinskii, A. V.
Format: Article
Language:English
Subjects:
Drug Synthesis Methods and Manufacturing Technology
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:A conjugate of erythropoietin β with 30 kDa linear methoxy poly(ethylene glycol) characterized by the presence of an azo spacer between the protein fragment and poly(ethylene glycol) was developed for import-substitution of Mircera drug in the Russian Federation. The erythropoietic activity of the synthesized conjugate was determined. Its pharmacokinetics in CBA mice were found to be comparable to those of Mircera. The bioequivalence of the proposed azo conjugate and Mircera was established based on the calculated drug pharmacokinetic parameters in mice.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-021-02480-3