Crystal Structure, Anticancer, and Antimicrobial Evaluation of a Novel Substituted Pyrazole Ligand and Its Co(II), Ni(II), and Zn(II) Complexes

Synthesis of substituted heterocyclic organic ligands and their metal complexes attract more attention in coordination chemistry in recent years owing to its interesting applications in pharmaceutical fields. In this research investigation, we designed a novel thio-substituted pyrazole ligand and sy...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2023-11, Vol.57 (8), p.1251-1259
Main Authors: Kumar, K. Subin, Reena, V. N.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:Synthesis of substituted heterocyclic organic ligands and their metal complexes attract more attention in coordination chemistry in recent years owing to its interesting applications in pharmaceutical fields. In this research investigation, we designed a novel thio-substituted pyrazole ligand and synthesized its three novel Co(II), Ni(II), and Zn(II) metal complexes. The ligand, thio-substituted pyrazole is characterized by using single crystal x-ray diffraction data and various physico-chemical measurements such as elemental analysis and UV-Vis, IR, 13 C, and 1 H NMR, and HRMS spectral techniques. X-ray single crystal measurement of the substituted pyrazole was made on a Brucker AXS Kappa APEX II CCD diffractometer with graphite monochromatic MoK radiation. Metal complexes were characterized by various physico-chemical measurements such as elemental analysis, molar conductance, magnetic susceptibility data, and various spectral data supports. Based on the data obtained from those measurements, an octahedral geometry was assigned to all metal complexes. Furthermore, biological applications of the synthesized complexes were evaluated, mainly their cytotoxic, antitumour, and antimicrobial activities. Zn(II) complex has shown eminent cytotoxic ability, with an IC 50 value of 46 μg/mL and its anticancer skill is scrutinized against “Ehrlich’s Ascites Carcinoma” cell line-induced ascites tumour and “Dalton’s Lymphoma Ascites” cell line-induced solid tumour in mice. Additionally, all the metal complexes showed promising antimicrobial skill against selected Gram-positive and Gram-negative bacteria.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-024-03031-2