Synthesis of 5,5′-(Disulfanediyl)bis[3-phenyl-1,3,4-thiadiazole-2(3H)-thione] and Study of Its Anti-Inflammatory Activity

5,5′-(Disulfanediyl)bis[3-phenyl-1,3,4-thiadiazole-2(3 H )-thione] was synthesized by oxidative condensation in the presence of chloride ions. The structure of the resulting compound was identified by an x-ray crystal structure analysis, for which the crystallographic data were obtained. The anti-in...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2024-03, Vol.57 (12), p.1898-1902
Main Authors: Shakirzyanova, G. S., Izotova, L. Yu, Kholbekov, O. Kh, Zhaloliddinov, F. Yu, Rakhmonova, G. G., Babaev, B. N.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:5,5′-(Disulfanediyl)bis[3-phenyl-1,3,4-thiadiazole-2(3 H )-thione] was synthesized by oxidative condensation in the presence of chloride ions. The structure of the resulting compound was identified by an x-ray crystal structure analysis, for which the crystallographic data were obtained. The anti-inflammatory activity of the synthesized disulfide was studied for the first time in a carrageenan edema model. 5,5′-(Disulfanediyl)bis[3-phenyl-1,3,4-diazole-2(3 H )-thione] was shown to have anti-inflammatory and antiexudative activity at doses of 10 and 20 mg/kg. Its effect was close to that of the drug Nimesil.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-024-03094-1