Modern Approaches to Mathematical Modeling of the Process of Direct Pressing of Tablets

The Heckel and Kawakita equations are the most common mathematical models used in modern studies of the pressing process to evaluate the mechanical properties of tablets. However, these classical models do not take into account the whole spectrum of processes occurring during interparticle interacti...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2024-07, Vol.58 (4), p.677-689
Main Authors: Markeev, V. B., Blynskaya, E. V., Tishkov, S. V., Alekseev, K. V., Alekseev, V. K.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:The Heckel and Kawakita equations are the most common mathematical models used in modern studies of the pressing process to evaluate the mechanical properties of tablets. However, these classical models do not take into account the whole spectrum of processes occurring during interparticle interaction, which necessitates the development of new approaches to modeling the tableting process. For this reason, a rather large number of direct- pressing models have now been developed. The choice of the optimal equation for each specific case has become a nontrivial problem. Currently used mathematical descriptions of the direct-pressing process were analyzed in the present study.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-024-03194-y