Stability of [(N-pyrrolidine)metylene]daunorubicin in aqueous solutions

The stability of [( N -pyrrolidine)metylene]daunorubicin (PMD) in aqueous solutions was studied in the pH range 0.42–12.03 at four temperatures. Its degradation was evaluated by using an HPLC method with UV detection (254 nm). The hydrolysis of PMD involved: (a) hydrolysis of protonated molecules of...

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Bibliographic Details
Published in:Reaction kinetics and catalysis letters 2009-10, Vol.98 (1), p.69-75
Main Authors: Jelińska, Anna, Uszak, Justyna, Cielecka-Piontek, Judyta, Zając, Marianna, Lamberti, Anna, Oszczapowicz, Irena, Łukawska, Małgorzata
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Chemistry and Materials Science
Industrial Chemistry/Chemical Engineering
Physical Chemistry
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Summary:The stability of [( N -pyrrolidine)metylene]daunorubicin (PMD) in aqueous solutions was studied in the pH range 0.42–12.03 at four temperatures. Its degradation was evaluated by using an HPLC method with UV detection (254 nm). The hydrolysis of PMD involved: (a) hydrolysis of protonated molecules of PMD depending on hydrogen ions and (b) spontaneous hydrolysis under the influence of water depending on the substrate charge.
ISSN:0133-1736
1588-2837
DOI:10.1007/s11144-009-0068-3