Reactivity and mechanism of action of selenochromenes used as an inhibitor for the radical chain oxidation of 1,4-dioxane

• Published in: Reaction kinetics, mechanisms and catalysis mechanisms and catalysis, 2020-10, Vol.131 (1), p.89-100
• Main Authors: Gerchikov, Anatoly Ya, Sharipova, Gulnaz M., Safarova, Irina V., Kurmakaeva, Natalya V., Hairullina, Veronika R., Spivak, Semen I.
• Format: Article
• Language: English
• Subjects: Catalysis; Chemistry; Chemistry and Materials Science; Industrial Chemistry/Chemical Engineering; Physical Chemistry
• ISSN: 1878-5190; 1878-5204
• DOI: 10.1007/s11144-020-01836-2

Organometallic compounds based on selenochromene are known as potential drugs. Currently in the creation of new drugs in pharmacology their role as antioxidants is given great importance, since this characteristic is important for inhibiting the possible radical chain oxidation processes of cell membrane lipids, which is the cause of much pathology. In this regard an important task of researchers is to study the mechanism and quantitative characteristics of the effectiveness of their antioxidative action. In this work, based on the previously studied kinetics of the antioxidant action of the additives 2-(4-biphenyl)-5,6-dihydro-4H-benzo-[h]-selenochromene (S1) and 2-(4-chlorophenyl)-4-phenyl-5,6-dihydro-4H-benzo-[h]-selenochromene (S2) in a model reaction of radical-chain oxidation of 1,4-dioxane (Khairullina et al. in Kinet Catal 54:14–17, 2013), by means of mathematical modeling a kinetic model of the process was constructed, with the help of which the analysis of the reaction mechanism was carried out, a complete kinetic picture of the process was obtained and stage rate constants.