One-pot synthesis of benzoquinoline and coumarin derivatives using Meldrum’s acid in three-component reactions

A series of 1-aryl-1,2-dihydrobenzo[ f ]quinolin-3(4 H )-one derivatives and 4-aryl-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin derivatives have been synthesized by one-pot multicomponent reaction of Meldrum’s acid with benzaldehyde, naphthalene-2-amine, or cyclohexanedione in PEG-400. The meth...

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Bibliographic Details
Published in:Research on chemical intermediates 2013-07, Vol.39 (6), p.2357-2367
Main Authors: Wang, Xue-Mei, Ye, He-Lin, Qaun, Zheng-Jun, Wang, Xi-Cun
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Physical Chemistry
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Summary:A series of 1-aryl-1,2-dihydrobenzo[ f ]quinolin-3(4 H )-one derivatives and 4-aryl-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin derivatives have been synthesized by one-pot multicomponent reaction of Meldrum’s acid with benzaldehyde, naphthalene-2-amine, or cyclohexanedione in PEG-400. The method has the advantages of mild reaction conditions, good yields, and easy processing, and is environmentally benign.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-012-0762-z