Microwave-assisted synthesis of 1,2,4-triazole-3-carboxamides from esters and amines under neutral conditions

A series of 1,2,4-triazole-3-carboxamides have been prepared from 1,2,4-triazole-3-carboxylates under mild conditions. Efficient synthesis of amides directly from esters and amines is achieved under mild, neutral conditions with liberation of alcohol as by-product. Both primary and secondary aliphat...

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Bibliographic Details
Published in:Research on chemical intermediates 2015-04, Vol.41 (4), p.1975-1984
Main Authors: Jaisankar, K. R., Kumaran, K., Raja Mohamed Kamil, S., Srinivasan, T.
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Physical Chemistry
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Summary:A series of 1,2,4-triazole-3-carboxamides have been prepared from 1,2,4-triazole-3-carboxylates under mild conditions. Efficient synthesis of amides directly from esters and amines is achieved under mild, neutral conditions with liberation of alcohol as by-product. Both primary and secondary aliphatic and aromatic amines can be utilized. This unprecedented, general, environmentally benign reaction proceeds in toluene under microwave conditions. The newly synthesized compounds were characterized by spectral and elemental analyses.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-013-1325-7