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Direct synthesis of cyanohydrin esters from aroyl chlorides using potassium hexacyanoferrate(II) as an eco-friendly cyanide source

A direct synthetic method for cyanohydrin esters from aroyl chlorides using potassium hexacyanoferrate(II) as an eco-friendly cyanide source and tributylphosphine as a promoter is described. This protocol has advantages of no use of strong toxic cyanating agents, high yield, and simple work-up proce...

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Bibliographic Details
Published in:Research on chemical intermediates 2015-05, Vol.41 (5), p.3147-3155
Main Authors: Li, Zheng, Zhao, Zhouxing
Format: Article
Language:English
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Summary:A direct synthetic method for cyanohydrin esters from aroyl chlorides using potassium hexacyanoferrate(II) as an eco-friendly cyanide source and tributylphosphine as a promoter is described. This protocol has advantages of no use of strong toxic cyanating agents, high yield, and simple work-up procedure.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-013-1421-8