Nano-manganese hydrogen sulfate as a novel catalyst for the anti-diastereoselective Mannich reaction in water

β-Amino carbonyl compounds are attractive targets for chemical synthesis, because they are widely used as biologically active compounds and are important synthons for a variety of pharmaceuticals. Nano-manganese hydrogen sulfate was prepared and used as a novel nano-catalyst for the named organic tr...

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Bibliographic Details
Published in:Research on chemical intermediates 2015-08, Vol.41 (8), p.5049-5058
Main Authors: Eshghi, H., Rahimizadeh, M., Javadian-Saraf, A., Hosseini, M.
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Physical Chemistry
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Summary:β-Amino carbonyl compounds are attractive targets for chemical synthesis, because they are widely used as biologically active compounds and are important synthons for a variety of pharmaceuticals. Nano-manganese hydrogen sulfate was prepared and used as a novel nano-catalyst for the named organic transformation, i.e. Mannich-type reaction of benzaldehyde, aniline, and cyclohexanone in water. Mannich products were obtained in high yields, with excellent diastereoselectivity, and short reaction time in the presence of a catalytic system comprising nano-Mn(HSO 4 ) 2 and a surfactant, for example sodium dodecyl sulfate. Use of mild, environmentally benign reaction conditions, low loading, and ready accessibility are the main features of this new catalyst. Graphical Abstract
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-014-1587-8