Oxalic acid dihydrate: proline as a new recyclable designer solvent: a sustainable, green avenue for the synthesis of spirooxindole

The quest to develop an environmentally friendly, sustainable protocol for immensely bioactive spirooxindole derivatives has encouraged to explore oxalic acid dihydrate: proline low transition temperature mixture as a new designer solvent for the said synthesis at room temperature. It has been succe...

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Bibliographic Details
Published in:Research on chemical intermediates 2016-02, Vol.42 (2), p.1411-1423
Main Authors: Chandam, Dattatray R., Mulik, Abhijeet G., Patil, Dayanand R., Deshmukh, Madhukar B.
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Physical Chemistry
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Summary:The quest to develop an environmentally friendly, sustainable protocol for immensely bioactive spirooxindole derivatives has encouraged to explore oxalic acid dihydrate: proline low transition temperature mixture as a new designer solvent for the said synthesis at room temperature. It has been successfully applied for the three component reaction of isatin, malononitrile or ethyl cyanoacetate and 1,3–dicarbonyl compounds for the first time. Moderate to good yield of the products, shorter reaction time, energy efficiency, chromatography-free purification process, recyclability and high atom economy are the captivating feature of this protocol which will find applications in multi-component, diversity-oriented synthesis. Graphical Abstract
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-015-2093-3