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Oxalic acid dihydrate: proline as a new recyclable designer solvent: a sustainable, green avenue for the synthesis of spirooxindole
The quest to develop an environmentally friendly, sustainable protocol for immensely bioactive spirooxindole derivatives has encouraged to explore oxalic acid dihydrate: proline low transition temperature mixture as a new designer solvent for the said synthesis at room temperature. It has been succe...
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| Published in: | Research on chemical intermediates 2016-02, Vol.42 (2), p.1411-1423 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c288t-2baf233ea08c2d76e15f4785f9d5c8577f6455faea4084f01b5740b5a17f4c863 |
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| cites | cdi_FETCH-LOGICAL-c288t-2baf233ea08c2d76e15f4785f9d5c8577f6455faea4084f01b5740b5a17f4c863 |
| container_end_page | 1423 |
| container_issue | 2 |
| container_start_page | 1411 |
| container_title | Research on chemical intermediates |
| container_volume | 42 |
| creator | Chandam, Dattatray R. Mulik, Abhijeet G. Patil, Dayanand R. Deshmukh, Madhukar B. |
| description | The quest to develop an environmentally friendly, sustainable protocol for immensely bioactive spirooxindole derivatives has encouraged to explore oxalic acid dihydrate: proline low transition temperature mixture as a new designer solvent for the said synthesis at room temperature. It has been successfully applied for the three component reaction of isatin, malononitrile or ethyl cyanoacetate and 1,3–dicarbonyl compounds for the first time. Moderate to good yield of the products, shorter reaction time, energy efficiency, chromatography-free purification process, recyclability and high atom economy are the captivating feature of this protocol which will find applications in multi-component, diversity-oriented synthesis.
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| doi_str_mv | 10.1007/s11164-015-2093-3 |
| format | article |
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| ispartof | Research on chemical intermediates, 2016-02, Vol.42 (2), p.1411-1423 |
| issn | 0922-6168 1568-5675 |
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| subjects | Catalysis Chemistry Chemistry and Materials Science Inorganic Chemistry Physical Chemistry |
| title | Oxalic acid dihydrate: proline as a new recyclable designer solvent: a sustainable, green avenue for the synthesis of spirooxindole |
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