Fluorine-containing quinazolines annulated at the pyrimidine ring

Fluorine-containing quinazolines annulated at the sides [ a ] and [ c ] were synthesized by the reaction of 2- and 4-hydrazino-substituted quinazolines with aldehydes and subsequent oxidative cyclization. Annulation at the side [ b ] was performed by alkylation of 2-alkylthio-4(3 H )-quinazolinones...

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Bibliographic Details
Published in:Russian chemical bulletin 2009-06, Vol.58 (6), p.1303-1308
Main Authors: Nosova, E. V., Laeva, A. A., Trashakhova, T. V., Lipunova, G. N., Slepukhin, P. A., Charushin, V. N.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Organic Chemistry
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Summary:Fluorine-containing quinazolines annulated at the sides [ a ] and [ c ] were synthesized by the reaction of 2- and 4-hydrazino-substituted quinazolines with aldehydes and subsequent oxidative cyclization. Annulation at the side [ b ] was performed by alkylation of 2-alkylthio-4(3 H )-quinazolinones with bromoethanol and ipso -substitution of the alkylthio group.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-009-0171-7