Adsorption of naproxen enantiomers from solutions on chemically modified cellulose. The effect of a polar component of a liquid phase

The influence of mobile phase composition (hexane-ethanol with the addition of 0.1 vol.% of trifluoroacetic acid) on the adsorption of the naproxen enantiomers on a chiral adsorbent Chiralcel OJ-H was investigated. Methods of linear and nonlinear chromatography were used to investigate adsorption th...

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Bibliographic Details
Published in:Russian chemical bulletin 2009-08, Vol.58 (8), p.1731-1735
Main Authors: Asnin, L. D., Kaczmarski, K., Reshetova, E. N.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Organic Chemistry
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Summary:The influence of mobile phase composition (hexane-ethanol with the addition of 0.1 vol.% of trifluoroacetic acid) on the adsorption of the naproxen enantiomers on a chiral adsorbent Chiralcel OJ-H was investigated. Methods of linear and nonlinear chromatography were used to investigate adsorption thermodynamics at infinite dilution and to measure adsorption isotherms for solutions containing 10 and 20 vol.% of ethanol. It was found that two groups of adsorption sites coexist on the surface of the adsorbent in contact with the mentioned solvent, strong and weak ones, with the strong adsorption sites contributing mainly to the adsorption of naproxen. The effect of ethanol content on the retention of naproxen consists of the change in the number of the strong adsorption sites and regulating solvation property of a solvent.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-009-0239-4