Synthesis, structures, and properties of 15-oxoisosteviol thiosemicarbazone and oxime

New nitrogen-containing derivatives of the diterpenoid isosteviol (16-oxo- ent -beyeran-19-oic acid) containing oxo, hydroxyimine, and thiosemicarbazone groups were synthesized. Isosteviol 15-oxo-16-thiosemicarbazone forms a 1: 1 complex with Cu II and inhibits the growth of Mycobacterium tuberculos...

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Published in:Russian chemical bulletin 2013, Vol.62 (1), p.175-182
Main Authors: Sharipova, R. R., Lodochnikova, O. A., Strobykina, I. Yu, Musin, R. Z., Babaev, V. M., Morozov, V. I., Pod“yachev, S. N., Chestnova, R. V., Kataev, V. E.
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description New nitrogen-containing derivatives of the diterpenoid isosteviol (16-oxo- ent -beyeran-19-oic acid) containing oxo, hydroxyimine, and thiosemicarbazone groups were synthesized. Isosteviol 15-oxo-16-thiosemicarbazone forms a 1: 1 complex with Cu II and inhibits the growth of Mycobacterium tuberculosis (H37R V , in vitro ) at the minimum inhibitory concentration of 20 μg mL −1 .
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Full Articles
Inorganic Chemistry
Organic Chemistry
title Synthesis, structures, and properties of 15-oxoisosteviol thiosemicarbazone and oxime
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