Three-component condensation of 3-aminothiophene derivatives with isatines and Meldrum’s acid. Synthesis of 2,5′-dioxo-3′-phenyl-5′,6′-dihydro-4′H-spiro[indoline-3,7′-thieno[3,2-b]pyridine]-2′-carboxylic acids

A method for the synthesis of 2,5′-dioxo-3′-phenyl-5′,6′-dihydro-4′ H -spiro[indoline-3,7′-thieno[3,2- b ]pyridine]-2′-carboxylic acids was elaborated based on the three-component condensation of 3-aminothiophenes, Meldrum’s acid, and isatines.

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Bibliographic Details
Published in:Russian chemical bulletin 2013-04, Vol.62 (4), p.1026-1031
Main Authors: Lichitsky, B. V., Belyi, R. M., Komogortsev, A. N., Dudinov, A. A., Krayushkin, M. M.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Organic Chemistry
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Summary:A method for the synthesis of 2,5′-dioxo-3′-phenyl-5′,6′-dihydro-4′ H -spiro[indoline-3,7′-thieno[3,2- b ]pyridine]-2′-carboxylic acids was elaborated based on the three-component condensation of 3-aminothiophenes, Meldrum’s acid, and isatines.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-013-0136-8