Synthesis, characterization, and antimicrobial activities of palladium Schiff base complexes derived from aminosalicylic acids

• Published in: Transition metal chemistry (Weinheim) 2017-04, Vol.42 (3), p.263-271
• Main Authors: Klaus, Jennifer A., Brooks, Taylor M., Zhou, Muyang, Veinot, Alex J., Warman, Alexander M., Palayew, Adam, Gormley, Patrick T., Ninh Khuong, B., Vogels, Christopher M., Masuda, Jason D., Baerlocher, Felix J., Westcott, Stephen A.
• Format: Article
• Language: English
• Subjects: Catalysis; Chemistry; Chemistry and Materials Science; Inorganic Chemistry; Organometallic Chemistry; Physical Chemistry
• ISSN: 0340-4285; 1572-901X
• DOI: 10.1007/s11243-017-0130-3

Six Schiff base compounds have been prepared from the condensation of o -vanillin, 2,3-dihydroxybenzaldehyde and 2,3,4-trihydroxybenzaldehyde with 4-aminosalicylic acid and 5-aminosalicylic acid (5-ASA). Addition of these Schiff bases to [Pd(OAc) 2 ] afforded the corresponding bis(salicylaldiminato)palladium(II) complexes in moderate to excellent yields. All new palladium complexes have been characterized fully using standard spectroscopic methods, elemental analyses and a single-crystal X-ray diffraction study in the case of 2e , the palladium complex containing Schiff base ligands derived from 5-ASA and 2,3-dihydroxybenzaldehyde. All derivatives of 5-ASA were examined for potential antimicrobial activities against two species of fungi, Aspergillus niger and Saccharomyces cerevisiae , as well as two species of bacteria, Bacillus cereus (Gram-positive) and Pseudomonas aeruginosa (Gram-negative).